Tourette syndrome

It is about my brother. He has been officially diagnosed some 15 years ago. In a community and country this undeveloped and prospectless, it is hard enough without having stigma-provoking and functionality disabling mental disorder.

It's really been hard time for him and it doesn't seem to get any brighter - a roller-coaster, ups and downs but no significant change generally. The thing is that he's been on so many different drugs prescribed by so many different doctors(klonazepam, anafranil, lexilium, prozac, zoloft, pimozid... just to mention some) and none of them had any effect - neither regarding the tics (compulsive articulation, motoric action, spitting) nor anxiety and uneasiness. I wondered if any of you guys had experience with some certain drug, or other kind of therapy for that matter, that had some definite effect. It has really been hell, and at least some alleviation of his soul pain would mean hope. Thanks in advance.