by Butterfly Faerie » Thu May 18, 2006 3:21 pm
The Facts
We all experience a variety of moods such as happiness, sadness, and anger. Unpleasant moods and changes in mood are normal reactions in everyday life, and we can often identify the events that caused our mood to change. However, when we experience changes in mood or extremes of mood that appear "out of the blue" and make it hard for us to function, these changes are often the result of a mood disorder.
Mood disorders are medical conditions that affect our ability to experience normal mood states, and there are mainly two types: major depressive disorder (also known as unipolar depression), in which all abnormal mood changes involve a lowering of mood, and bipolar disorders (formerly known as manic-depressive disorder), in which at least some of the mood changes involve abnormal elevation of mood.
Bipolar disorder typically begins for people during their mid-twenties. It is unusual for bipolar disorder to begin in childhood without strong familial risk factors and it is rare for its onset to occur after the age of sixty (unless associated with another medical condition). Bipolar disorder occurs in about 2% of the adult population.
Causes
There is no single, proven cause of bipolar disorder, but research suggests that it is the result of abnormalities in the way some nerve cells in the brain function or communicate. Researchers also believe that there is a definite genetic link (family history), in which there is a higher risk for people who have a parent or full-sibling (i.e., a first-relative) with bipolar disorder.
Whatever the precise nature of the cause underlying bipolar disorder, it clearly makes people with the disorder more vulnerable to emotional and physical stresses. As a result, upsetting life experiences, alcohol, illicit drug use, lack of sleep, or other stresses can trigger episodes of illness, even though these stresses do not actually cause the disorder.
Mood disorders are not the fault of the person suffering from them. They are not the result of a "weak" or unstable personality. Mood disorders are treatable medical illnesses for which there are specific medications that help most people.
Symptoms and Complications
Bipolar disorder is a condition in which the person's mood changes in cycles over weeks to months. The nature of mood changes vary from one person to the next. There are four different kinds of mood states or "episodes" in bipolar disorder and these are described in further detail below: mania, hypomania, depression, and mixed episodes involving symptoms of mania and depression. Over the course of the disorder, a person may go through periods of elevated mood, depressed mood, and times when mood is normal.
Mania often begins with a pleasurable sense of heightened energy, creativity, and social ease. However, these feelings quickly progress to full-blown euphoria (extremely elevated mood) or severe irritability. During a manic episode, the person will also have at least four of the following symptoms for at least one week:
needing little sleep
talking so fast that others cannot follow you
having racing thoughts
having hyperactivity or agitation
being so easily distracted that your attention shifts between many topics in just a few minutes
having an inflated feeling of power, greatness, or importance
doing reckless things without concern about possible consequences (e.g., spending too much money, engaging in inappropriate sexual activity, or making risky business investments)
Hypomania is a milder form of mania that has similar but less severe symptoms and has less negative impact on a person's daily activities. During a hypomanic episode, the person may have an elevated mood and be more productive. Because these episodes often feel good, the quest for hypomania may even cause some people with bipolar disorder to stop taking their medications. However, a person does not usually stay in a hypomanic episode for long and gradually shifts into either mania or depression.
Depression: During a depressive episode, the person experiences feelings of sadness or loses interest in the things one normally enjoys. At least four of the following additional symptoms persist for at least two weeks:
insomnia (trouble sleeping) or sleeping too much
loss of appetite or eating too much
decreased interest in pleasurable activities
fatigue or loss of interest
problems concentrating or making decisions
feeling slowed down or feeling too agitated to sit still
feeling worthless or guilty or having very low self-esteem
recurring thoughts of suicide or death
Mixed episodes: The most disabling episodes are those that involve symptoms of both mania and depression together, or alternating frequently during the day. Individuals are excitable or agitated as in mania, but they also feel irritable and depressed. Mixed episodes present the highest risk of suicide. Up to 15% of all people with bipolar disorder may commit suicide.
In severe cases of bipolar disorder, the person may also experience psychotic symptoms which are hallucinations (hearing or seeing things that are not there) or delusions (firmly believing things that are not true).
Patterns of bipolar disorder
People with bipolar disorder vary in the types and frequency of episodes that they experience. Some people may have equal numbers of manic and depressive episodes, while others may have mostly one type or the other. On average, a person has four episodes during the first 10 years of having bipolar disorder.
While several years can pass between the first few episodes, without treatment most people eventually have more frequent episodes. Episodes can last for days, weeks, months, or sometimes even years.
Classifications
According to the episode patterns, bipolar disorder can be classified as:
Bipolar type 1 - a person has one or more manic episodes, usually accompanied by major depressive episodes.
Bipolar type 2 - a person has only hypomanic and depressive episodes, not full mania or mixed episodes. Hypomania often seems normal to the person, and they seek treatment only for depression.
Rapid cycling bipolar disorder - a person has at least four episodes per year in any combination of mania, hypomania, mixed, or depression.
Making the Diagnosis
A doctor will diagnose bipolar disorder based on a pattern of symptoms. Diagnosis usually involves a thorough medical history, questions about family history, a physical exam, and a psychiatric evaluation that assesses the history of depression and mania episodes.
Early and proper diagnosis is an important step towards preventing other complications such as suicide; alcohol or substance abuse; marital or work problems; and more frequent cycling episodes.
Treatment and Prevention
People with bipolar disorder will receive treatment to manage their current episodes as well as treatment on a long-term basis to prevent future episodes. Components of treatment include medications, education, and psychotherapy. Electroconvulsive therapy (ECT) is usually reserved for people who do not respond to treatment with medications for bipolar disorder.
Medications: Treatment for bipolar disorder must be customized to fit the individual because the patterns and severity of this disorder vary from one person to the next. Long-term medications are commonly used to treat bipolar disorder. Medications used to manage bipolar disorder are as follows:
Mood stabilizers: Most people with bipolar disorder are treated with medications called mood stabilizers (e.g., lithium*, divalproex or valproic acid, carbamazepine). These medications provide relief from current episodes, prevent them from recurring, and do not worsen depression or mania, or lead to increased cycling. Sometimes other medications normally used to treat people who have epilepsy are used to treat symptoms of bipolar disorder (e.g., gabapentin, lamotrigine, topiramate). Combination therapy with two mood stabilizers is sometimes recommended for people who do not respond to or develop resistance to the use of one medication. These medications need to be closely monitored by the doctor.
Antidepressants: These medications treat the symptoms of depression, and they work by altering the levels of certain chemicals in the brain in a way that elevates a person's mood. For people with bipolar disorder, antidepressants must be used together with a mood stabilizer medication to prevent cycling into a manic episode. Many types of antidepressants are available, working in different ways, and with different side effect profiles.
Other medications may be prescribed by the doctor for other problems associated with bipolar disorder such as medications for sleeping, anxiety, restlessness, or thought disturbances.
It is important for people with bipolar disorder to keep taking these medications in order for the drugs to work properly in managing this condition. Do not stop taking these medications or adjust the dose on your own, without speaking to your doctor or pharmacist first. Symptoms that recur after medications have been stopped are sometimes much harder to treat. Talk to your doctor and pharmacist if you have any questions about the medications you are taking and ask about possible side effects.
Education and counselling: Learning more about bipolar disorder and seeking counselling can help people and their families learn how to best manage the condition and prevent other complications from occurring.
Psychotherapy: Psychoeducation (or psychotherapy) is usually combined with medication to help people with bipolar disorder and their families understand and deal with the medical condition. Specific psychotherapies (cognitive behavioural, interpersonal, and problem-solving therapy can be as effective as antidepressants in treating the depressive episodes in bipolar disorder).
Other things that a person with bipolar disorder can do to help reduce symptoms include:
learn to recognize early warning signs of a new mood episode
try to get enough sleep, and go to bed at a regular hour each night
exercise regularly
avoid alcoholic beverages and street drugs
reduce stress at work and in everyday life
eat a well-balanced diet
keep a diary to track your daily feelings, activities, sleep patterns, life events, and side effects of medications. This will help you and your doctor determine which treatment works best for you.
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*All medications have both common (generic) and brand names. The brand name is what a specific manufacturer calls the product (e.g., Tylenol®). The common name is the medical name for the medication (e.g., acetaminophen). A medication may have many brand names, but only one common name. This article lists medications by their common names. For more information on brand names, speak with your doctor or pharmacist.