I find the whole dopamine thing interesting, because in some ways i find it hard to figure out where my own levels are.
Recently (when under stress) I responded very badly to dopamine-reducing medication (antipsychotic) which sent me to sleep and made me wake up feeling like $#%^. But i haven't always had the exact same problems, and stress reduces dopamine levels... trying to deal with my own problems has put me under a lot of stress over the last couple of years.
On one hand i relate to some of the symptoms not specific to concentration, and on the other hand, i can go the other way, i feel like things like exercise for example can make my dopamine levels skyrocket, which makes me wonder, maybe my exercise addiction really was a good thing, and it might be healthy for me to get another one going!
I remember when i was in the unit as a teenager they'd comment i was lethargic a lot of the time and that at times, for example after exercise, i'd seem "high" - one of their arguments for the bipolar dx i expect. Also in other circumstances, I've noticed the same effect.
so i feel more like i have dysregulated dopamine levels than chronically low ones, though stress tends to push them low, and that i'd be more likely to benefit from something that might help stabilise them within an area in the middle... which might - or might not explain something -
this is interesting: (about dopamine responses tested in mice, mainly about lithium but also touches on responses to amphetamine.)
[article based on animal testing.]
http://www.pnas.org/content/101/14/5099.full wrote:These data support the involvement of GSK-3 as an important mediator of DA and lithium action in vivo and suggest that modulation of the Akt/GSK-3 pathway might be relevant to DA-related disorders, such as attention deficit hyperactivity disorder and schizophrenia.
it interested me because when i was 15 i managed to stay at school for 8 months and function while on lithium.
i dont know if it was really anything to do with it or not, because i still exploded on things when i got sick of it, but i was going in every day and functioning at least to that extent, where as the exploding at it all was a psychological response based on my issues and perspectives, so its possible it did something.
Interestingly it didn't stop me getting depressed though, which is what its supposed to do in people with bipolar, but for that 8 months at least i seemed more functional, controlled etc. at least until i got pissed off with it all lol.
I'm not inclined to try going back on it because of the potential long term effects, but it would be interesting to find out what measures might be possible to use to simulate that effect if it was helpful.
i also dont think i actually have ADHD personally, i lack most of the concentration issues involved, but i noticed the post and found it interesting.