Hello, this is my first post to this forum. Please have patience with me this first time around at least until I learn a bit more about my way around here.
I found this special forum for the first time about 10 days ago. This is a subject (situational retarded ejaculation) of great interest to me because I've also experienced retarded ejaculation and numbness intermittently over the last ten years and have spent many hours researching the subject on the internet and the National Library of Medicine at
www.pubmed.gov.
It started rather abruptly when I was about 52-53 years old and it all begin for the first time in my life after I started taking antidepressants for a condition that I was supposed to have had called fibromyalgia and a related sleep problem. I was started on trazodone (which didn't help my pain syndrome) followed by amitriptyline (Elavil), citalopram (Celexa), venlafaxine (Effexor), and now bupropion SR (Wellbutrin) at 150 mg for the last 2 1/2 years. Celexa and Effexor caused the most problems before trying Wellbutrin. Going to Wellbutrin at 150 mg helped some but my RE problem definitely did not improve when I went up to 300 mg for a period of time. Now I'm back on 150 mg per day and the problem with RE and numbness has lessened but has not totally gone away.
In July 2003, I was also put on testosterone by using a 10% cream compounded by a local compounding pharmacy and have used it intermittently since then. It does not appear to have helped me in any significant way.
It turns out that pain in my shoulders and arms was not caused by fibromyalgia but rotator cuff disease, osteoarthritis and referred pain as well as a type of thyroid condition (with supposedly normal TSH values but low free T4 and free T3). Treatment began in July of 2003 with thyroid medication and small amounts of hydrocortisone (Cortef) and within 3 weeks, 90 percent of my pain was gone forever. In May of this year I had very successful surgery for a tear in my rotator cuff of my left shoulder and more of the remaining pain was resolved.
After reading all 26 pages of the posting on this forum, I thought that I would share some of my experiences as a preface to the following ideas and information that I found on the internet and pubmed.
To me the most interesting study on situational retarded ejaculation was just published in the Journal of Clinical Endocrinology and Metabolism on October 4, 2005. The 25 page study is entitled, Multicenter Study on the Prevalence of Sexual Symptoms in Male Hypo- and Hyperthyroid Patients by well known endocrine and sexology researchers from Italy. These are some quotes. "Ejaculation Latency Time ... for hypothyroid men it declined significantly, from 21.8+-2.1 to 7.4+-7.2 minutes. Thyroid stimulating hormone (TSH) and thyroid hormone levels normalized rapidly following treatment, and changes in circulating sex steriods partially reflected the changes in Sex Hormone Binding Globulin (SHBG) levels. Conclusions: In summary, most patients with thyroid hormone disorders experience some sexual dysfunctions, which can be reversed by normalizing thyroid hormone levels. In spite of the associated changes in sex hormone levels, the high prevalence of ejaculatory disorders and their prompt reversibility suggest a direct involvement of thyroid hormones in the physiology of ejaculation." This study is available without charge and can be downloaded.
LC Newman, SW Broner, and CL Lay have published an article in a journal, Neurology. 2005 Oct 25;65:( 8 )1333-4 entitled, Reversible Anorgasmia with Topiramate Therapy for Migraine. note: I can't read this 2 page article without paying a 1 day fee of $20 to access this article. It's too much! Topiramate (brand name: Topamax) is an anticonvulsant drug also used for migraine headaches. Supposedly it can be used off label for anorgasmia.
Several years ago I purchased a used copy of the book: Sexual Pharmacology: Drugs That Affect Sexual Functioning by Theresa L. Crenshaw and James P. Goldberg. The $75.00, 596 page book published in 1996 by Theresa L. Crenshaw and James P. Goldberg, eventhough dated has lots of information regarding medicinal drug use and ejaculation irregularities including retarded ejaculation and ejaculation without orgasm. For example, on page 274, it indicates that tricyclic antidepressants can cause negative sexual affects such as increased prolactin and increased serotonin as well as decreased oxytocin, histamine, cholinergic activity, beta-adrenergic activity. This book can be gotten as a used book on amazon.com at a price from $10.75-37.25 plus shipping. There are as many as 32 used or new ones available as of 11/28.
Bicycle seat neuropathy can cause temporary sexual problems after injury by compression of the pudendal nerve in the pelvis area. This is one of the more common injuries reported by cyclists. If this vascular or neurologic injury to the pudendal can happen in cyclists why can't it on occasion happen depending on where and how we use our pelvis and sit on our "buns"! On page 293, March 2001, Psychiatric Sevices, vol 52, no 3, Men's Sexual health After Midlife, delayed ejaculation, it says, "Peripheral nerve damage to the penis or damage at the level [of] the S2-4 [sacral] nerve roots can also delay orgasm."
I challenge all of us to make sure we work at determining whether our RE problems are psychological (depression, anxiety, social stressors), organic (arterial, venous), neurogenic (diabetes, herniated disk, alcoholism), hormonal (low testosterone, elevated prolactin, thyroid deficient), caused by trauma/injury or something else. There's so much to be discovered yet. Only the surface has been touched with RE.
One final comment. For your own curiosity, consider going to
www.pubmed.gov, and type in retarded ejaculation, anorgasmia, ejaculatory latency or something similar with words like prolactin, oxytocin, vasopressin, testosterone, dopamine, SHBG, thyroid, hypothyroidism, iodine, selenium, ascorbic acid, cGMP, endorphins, cytokines, VIP, CRH, estrogen, ACTH, sleep apnea, nitric oxide and join me in seeing what we might find.