Hey guys, what sort of medications have alleviated any SPD symptoms of yours? (Such as anhedonia).
I have somewhat recently identified as schizoid/avoidant behaviour, as well as pre-existing ADHD-PI which I know understand to be comorbid to negative symptoms such as anhedonia and apathy. I did not recognize these symptoms prior due to alexithymia. My inquiry pertains to an upcoming psychiatric appointment to address my ADHD and negative symptoms.
I have a strong interest in pharmacology and have safely experimented with many supplements and uncontrolled pharmaceuticals, only after much extensive research of course, as well as the three controlled prescription drugs: methylphenidate, dextroamphetamine, and quetiapine. Mind that none of these drugs were used intentionally for a recreational high, both stimulants were used as last attempt study aids in two isolated occasions, and the quetiapine to test if I experience any positive psychotic symptoms (through notice of any alleviated symptoms, please remember I do experience debilitating alexithymia). Accordingly I respond well to stimulants, particularly releasers such as dextroamphetamine, as I found reuptake inhibitors to be very erratic. Elevating one minute, the next dysphoric and agitating, which I perhaps link to a few studies that implicate possible polymorphisms in alleles that encode the dopamine transporters, although I could be like many others and respond poorly to methylphenidate. Regardless, dexedrine made me feel "normal" if I must be cliched. Apart from the huge emotional rebound I felt, I once again enjoyed my previous hobbies and interests, and had a much higher comparative percentile in visuospatial memory and visualization ability.
Not to delve further into jargon but later along the line I decided to import L-Deprenyl into use. Long story short it cured any depression and mildy relieved attention and anhedonic symptoms, but not to a satisfactory extent. I can fairly say at this point that dopaminergics are what I recieve most relief from, and contrastingly I experience worsened hedonic tone from dopamine antagonists.
With all I've previously stated, is there any likelyhood I will be able to persuade my psychiatrist towards an augmentation therapy of: low dose dexedrine as the base for dopamine release to mitigate anhedonia/inattention, memantine for tolerance prevention/neuroprotection/and additional D2 agonism (seeing as low D2 has most implications in S/A behaviour), and amisulpiride to selectively inhibit presynaptic D2/D3 autoreceptors and force upregulation on days off of dex? I have other ideas up in the air I'd like his input on, but this seems to me like a far more selective and suitable treatment as opposed to something with a more crude overall effect in relieving anhedonia like Wellbutrin.