Currently, various common mental disorders, and especially depression, OCD, and schizophrenia, are treated with drugs whose most prominent effect is to cause hyperprolactinemia. Such drugs include the SSRIs, and the D2 receptor antagonists, such as risperidone and paliperidone. Hyperprolactinemia causes long-term sexual anhedonia, probably via an epigenetic mechanism that shuts down a dopamine-related gene in neurons, in response to the very high prolactin.
The pharmaceutical companies that manufacture the hyperprolactinergics deceptively call them 'anti-depressants' and ...