That do not involve hallucinogens.
The TL;DR is that the FDA has approved a pill that combines the cough suppressant dextromethorphan with a little buproprion (Wellbutrin). It's the cough medicine that actually relieves the depression, and the Wellbutrin component slows the metabolizing of the dextromethophan and keeps it active.
https://youtu.be/ESvvAMWXuM4