Severe long-term depression-Treatments and ways to cope

I have been diagnosed with severe long-term depression (along with Avoidant PD and GAD) and I've been on numerous medications (antidepressants, mood stabilisers, antipsychotics, benzos) and had therapy for a number of years. I'm just wondering what treatments you guys have tried and any successes you have had? Also, how you've learned to cope with the unremitting symptoms?

What problems are you experiencing in life?

Relationships?

Given my Avoidant PD, I'm always going to have difficulty with relationships. But even with this, a number of professionals have diagnosed me with endogenous depression as separate to the PD (I was diagnosed with depression in childhood with a query of bipolar). I also have a strong familial loading for both severe (at times catatonic) depression and Bipolar type ii. I know external things can trigger it sometimes, but other times it is unpredictable, and I'm just wondering others experiences of this type of depression and how they cope with/manage it.