by twistednerve » Tue Dec 31, 2013 10:41 pm
I'm a 27 year old male, and I also started having severe depression about 2 years ago. It didn't start with my first panic attack, but it was then that it became noticeable and got much worse a few months later.
I have also noticed the cognitive impairment in me, and it's really bothering me as well. Did my fair reading about it and discussed it with doctors, and it doesn't seem like something to worry. Though it can get severe and really hurt areas of your life where cognition is a must, it should improve along with the improvement of depression. Get your depression in check, and cognition will return to normal.
Many people claim to have poor concentration, memory and motivation to study when depressed. It is actually expected for a great number of biological and psychological factors. Though in most cases it's just an acute symptom of depression, stress, depression and lack of sleep can cause real changes to your brain and damage some of it, which can cause lasting effects on cognition.
Serotonin based drugs (Cipralex is one of them. SSRI is the main class of drugs used to treat depression and they target serotonin primarily) seem to be the best at improving long term brain damage from stress and depression. Serotonin helps the brain repair existing neurons and promotes neurogenesis, the creation of new neurons, which can in itself improve depression and greatly improve it's cognitive symptoms.
Lithium has also neuroprotective properties. It regulates the levels of glutamate in the brain, reducing it's toxicity to the brain cells, focus serotonin on the hypocampus, which improves memory and emotional regulation, amongst other things. Good thing is, for depression and maintenance of the brain, you can take a low dose of it, which barely has any side effects.
Now, if you absolutely must improve your cognition right away, I would suggest norepinephrine reuptake inhibitors (NRI). Norepinephrine is greatly responsible for motivation, alertness and energy. Depressed people often feel a lot of improvement with drugs that increase norepinephrine.
Norepinephrine also promotes the circulation of dopamine in the brain, the neurotransmitter responsible for attention, focus, desire, pleasure, rewarding, learning, etc.. There are drugs that directly increase dopamine (stimulants such as Adderal, Ritalin and dopamine reuptake inhibitors such as Welbutrin), but for depressed people they can be too stimulating and actually generate more anxiety, insomnia and depression.
Note that serotonin causes a natural downregulation of dopamine in the brain, which in turn can cause even more lack of mental focus, difficulty learning, forgetfulness and apathy. SSRIs are the worst drugs when it comes to that.
Also, are you taking sleeping or anxiety pills? Benzodiazepines can be very hard on attention and specially memory.
Hope this post helps you.