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Defects of or related to agmatine transport cause psychosis?

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Defects of or related to agmatine transport cause psychosis?

Postby ornithine » Mon May 26, 2014 9:30 am

I think a defect in or related to agmatine transport may be the cause of my disorder.

I previously posted on the over-expressed pathways that I thought were probably present in my disorder. These were presumed over-expression of pathways from:
1. Proline to ornithine decarboxylase to polyamines;
2. Arginine to NOS to NO to cGMP to cGMP dependent protein kinase; and
3. The urea cycle to creatinine.

I assumed that my arginase must be under-expressed because it leads from arginine to ornithine and citrulline (my ornithine and citrulline were low and on the low side respectively). Also, if my arginine is diverted away from the urea cycle to NOS as outlined above, it would follow that arginase is under-expressed. This is also pointed to by the borderline low urea/low urea that the disorder presents with when it is acute.

Thus, I was looking for a defect that would cause high ornithine decarboxylase activity, high NOS activity, high activity along the arginine to creatine pathway and low arginase activity. My reading of research is that agamatine/agmatine decarboxylase does all of this.

Agmatine is also an amine and I have food intolerance to amines. It is reported to cause diarrhoea and I have this. It is reported to be protective for lower back pain and neuro-protective and me and my father have/had lower back pain and pre-clinical, early onset symptoms of dementia and Parkinson’s, whilst my paternal grandmother had dementia and Parkinson’s. There is a suggestion that agmatine may be linked to rheumatoid arthritis which my father’s sister, who I am confident has the same disorder as me, also had.

I also suspect agmatine to be linked to G6PD via agmatine's reported connection to cGMP and thus to cGMP dependent protein kinase which is linked to G6PD. G6PD is strongly associated with psychosis, which my familial disorder presents with.

If I am right, how many more people have agmatine related disorders that have found expression in various disease states including dementia, I wonder.

I am not a doctor. The above is from memory. So please do not rely on it without properly verifying the information.
ornithine
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