Quinolone as possible trigger?

Hello,

My 20-year-old daughter was dx'ed with BP three years ago. She has been stable on her meds since her dx.

Recently, she has had a relapse (if that is even the correct word) that we believe to be due to her having been on Avelox, a quinolone antibiotic, for 14 days.

I found many online citations implicating the quinolones in CNS stimulation, but I was wondering if anyone else with BP specifically has experienced this phenomenon.

Thank you.

Tricia

I would do some more research, but from my experience, when ever I take antibiotics or am recovering from an illness, I go into a depression. REsulting in alot of over sleeping, then I trigger to mania, because of the sleep. Let me see what I can find on this. okay?

I think I found the answer for you. @

http://64.233.161.104/search?q=cache:1f ... ions&hl=en

On another site that I lost it indicated that that particular type on Antibiotic, hits the central nervous system and can result in mood changes.

Some docs are rxing it to treat bipolar here are the results. They are not good.

http://www.fqresearch.org/news_of_the_day_8.htm

My advice after long study, is a mother insight is always true. Get her off this med. There are other antibiotics for bacteria, if she has a bacterial infection, antibiotics do not cure viruses.

Yet more info for you. http://www.medicinenet.com/moxifloxacin ... rticle.htm
My best to you both

Hi,

I wrote a reply to your first post, but I see that it didn't "take". Let's hope this one does.

Thank you for all of the research you did. My 20-year-old daughter, who attends college in a neighboring state, is in some legal trouble, and I'm trying to explore all possible options to help her out. I will read carefully the material to which you provided links.

She was diagnosed with bipolar disorder three years ago, and has been stable on her meds since her dx. She finished a 14-day course of Avelox for a sinus infection last Thursday (April 7). She
commented to me a few days later that she had felt unusually anxious and "out of it" while on the Avelox, and was continuing to experience these strange symptoms as of that Sunday morning. I chalked it up to coincidence, because at the time, they seemed to me to be peculiar side effects for an antibiotic. (I now know otherwise...)

Unfortunately, my daughter is now facing an underage drinking citation (with a mandatory license suspension) because she began to drink that same Sunday night while out with friends. She had never before this time consumed any alcoholic beverages, knowing full well about the dangers of combining alcohol with her meds, no to mention being underage. The young man who was driving my
daughter's car at the end of the evening, because she knew she was incapable of doing so herself, was pulled over and charged with a DUI, and my daughter with UAD and "public intoxication".

We are, of course, devastated by these events. I am wondering,
however, if it is possible that the Avelox contributed to a triggering
of bipolar symptoms, causing her to indulge in the reckless
behavior that led to her intoxication. If so, then perhaps we have a defense of sorts, or, at least, "mitigating circumstances".

Now, please don't get me wrong. If my daughter didn't have a mental illness that can cause bizarre and uncharacteristic changes in behavior, then I would not be trying to make excuses for her. Both of my kids know how dangerous alcohol is, and both also know that underage drinking is against the law. Period.

I really feel, though, that she was not fully in control of her actions before she even took that first drink. Based on what I have read to date, the quinolone class of antibiotics has been shown to induce mania in patients without any previous history of a mood disorder. I have yet to see, however, any specific link between quinolones and BP.

Needless to say, my daughter was not warned by her allergist of potential dangers in taking Avelox with her BP, nor did the informational leaflet provided with the medication mention any
such concern.

Below are a several links I found on the subject of quinolone "toxicity". Perhaps they will help someone else.

http://interactive.wsj.com/fr/emailthis ... 969960.djm

http://www.fqresearch.org/index.htm

http://www.medicationsense.com/articles ... other.html

http://www.postgradmed.com/issues/1997/ ... eckman.htm

Thank you again for your help. I'll let you know how we make out.

P.S. I just tried to post this and was informed that my username had been taken; yet, I received an e-mail confirming my user name and password when I registered. Let me try again.

When I attempted to post my last reply, I had apparently not logged in, so when I tried to post as TriciaJ, I was technically a guest and was informed that the name was already in use. Of course, it was: I was TriciaJ! (What an idiot!)

Public drunkenness, what did she do? They don't arrest the passenger unless they have a warrent. or are acting up after being warned by the officer at the scene.

Alot of meds can increase the affects of alcohol. This is a good question for your attorney, i.e. did they do a breathalizer or field sobriety. Did they do the breath. on the site or wait , waiting increases blood alcohol in 45 min after the drinking stops, like a .o6 can rise to .09 and be illegal. Tho she was on meds, this could make the case worse. even if she wasn't driving. That may be the reason for the charges being so obscure. They had nothing else to get her with. cops are strange that way.

But I would print the papers you have and take to your lawyer. If this is her first offense and it's just public drunkenness, she will get a slap on the wrist in most states. you have a good case. and she learned a valuable lesson. I'm just glad they are both safe.