Continuos muscle twitches after olanzapine and mirtazapine.

Hello everyone,
my name is Nicholas and I'm a 21 years old guy from Italy.
I suffered from chronic insomnia from the age of 15 and in mid-February 2017 was prescribed before bedtime the antidepressant mirtazapine at 15 mg and the antipsychotic olanzapine at 2,5 mg. I took them for 2 weeks without improvement. Therefore the psychiatrist increased mirtazapine at 30 mg and olanzapine at 10 mg. Now I believe that he thought I had bipolar disorder type 1 but I hadn’t any mental illnes.
I took olanzapine at 10 mg because I think was only a tranquilizer and because I trusted the doctor.
Olanzapine made me sleep for 13 hours but I was no longer myself. After 5 days I tried to split the tablet but it gave me a strange effect. So I continued for others 15 days at 10 mg because I really needed to sleep. Then in April 2017 I tapered olanzapine in 1 week because I could not live anymore like that. I took it for a total of 48 days.
After this I reduced mirtazapine to 15 mg and 1 week later I stop cold turkey. At that time I took the benzodiazepine brotizolam at 0,25 mg for 2 weeks to help me sleep.
The withdrawal symptoms were terrible for 4 months and I have not been the same anymore.
When I was on mirtazapine and olanzapine I had eyelids fasciculation 2 or 3 times per day. When I quitted olanzapine the eyelids fasciculation ceased.
2 weeks after withdrawal from olanzapine and 1 week from mirtazapine I started to have frequently intermittent muscle twitching in the left thigh and occasionaly pulsating muscles in other parts of the body. After less than a couple of months they have decreased in frequency and intensity but didn’t stop completely. During this period I was forced to take the antidepressant sertraline and the benzodiazepine diazepam because for the new psychiatrist I had obsessive compulsive disorder with an obsession for the damage of antipsychotics. I did not have anything like that and could taper and withdraw after 3 months in July 2017.
Now I think maybe that the muscles twitching have diminished because diazepam is also a muscle relaxant.
In August 2017 I started to have continuous fasciculations in the legs when I lie down and less frequently when I sit while I never had them when I move. Few times a day I had pulsating muscles also in the arms and the trunc but never in the face. I never had muscle twitches in multiple parts of the body at the same time.
In September the muscles twitching moved for 1 week in the lower abdominals.
In October 2017 for 2 weeks the muscles twitches suddenly stopped in the legs and continued in the rest of the body about 10 times per day.
When the muscles twitching returned they were milder. Sometimes the fasciculations are so mild that when I looked at my calf I saw them without feel them. In the legs they have become more single rapid muscular contractions than pulsating muscles.
Soon after I started to have continuos pulsating muscle in my upper lip. The muscle twitch was very mild and lasted 2 weeks but after it I have sometimes pulsating muscle also in my face.
Do you think it is a tardive dyskinesia caused by olanzapine despite I haven’t involuntary body movements?
Do you think it could be some other side effect caused by olanzapine or maybe mirtazapine? It’s 8 months that I’ve it.
I have been visited by several psychiatrists and neurologists and everyone said it was just stress.
Even if I do not have the symptoms of tardive dyskinesia I do not know what else it could be: I’m not stressed and I do not suffer from anxiety, I do not take stimulants, I can sleep, I have had blood tests and I haven’t electrolyte imbalances or hypoglycemia, I did electromyography and had normal results.
The thing that worries me most is that there is a very large amount of medical literature that associates tardive dyskinesia with cognitive impairments.
If it were to be tardive dyskinesia do you think that the fact that for almost 2 weeks the muscles twitches had almost disappeared means that I am healing?
Thank you and greetings from Italy.

My nose twitches even after stopping lithium. It started when I got on higher doses of it. I did a weird thing with my lips and speech, but that stopped after getting off lithium. The lower dose didn't cause this, only when I got up to the maximum amount that I could tolerate and that did help with getting me stable, but I had those side effects, plus a few others. I got off it.

I've only recently been prescribed Olanzapine, and it makes my right eyelid (?) twitch sometimes. I'm not awake for very long on it, so I might be twitching some more in my sleep. This happened, perhaps, on the first or second day that I had taken it. I honestly hadn't thought about it very much before reading this post. It isn't a frequent twitch.

i have been on anti-psychotics for over 30 years but in the past its been zyprexia and haldol that have done me in. Now I am being treated for focal seizures which even on meds are not controled. I cant really pinpoint this to the meds since I have had TBI in the past. I have been suffering with tremors and unsteady gait, memory problems short term and long term. They are telling me that I am suffering with parkinsonism and I am still on lithium, seroquel and now thorazine. They are telling me symptoms will not get better and may bet worse as i get older.

Hi Risilox,

It sounds as if the muscle twitches are distressing and confusing for you, so I hope you get the answers you need soon as to what might be causing them. I'm sorry if you've already mentioned it, but have you asked your current psychiatrist about the twitching? Maybe they'd be able to answer your questions and/or provide a medication to prevent the twitches from happening.

I can't comment on Mirtazapine, as I've never been on it, but I am on 10mg Olanzapine and it gives me oculogyric crisis (uncontrollable upwards rolling of the eyeballs), for which I take Procyclidine. I think this side effect is classed as a dystonic reaction, which is a type of extrapyramidal symptom. I find it upsetting and annoying when it happens, so days when I'm out of the house or seeing people, I make sure I take my Procyclidine to counteract it. I know from past experience that when I discontinue the Olanzapine, the oculogyric crisis stops happening, too.

Anyway, this was just some of my experience of involuntary movements from Olanzapine- not the same as twitching but hopefully you'll find it somewhat helpful.