HELP! Effexor XR Once a Day Isn't Enough. Twice Seems Better

Hello all. I just changed the way I'm taking My Effexor XR. I am now taking it all in the morning rather than 37.5 in the am & pm.

I've noticed since I started dosing this way that I wake up feeling really weird. Even before it's time for my next dose.

I believe the XR formulation has a half-life of like 10 hours or something. So if that's the case, does that mean I might be experiencing a bit of withdrawals?

I like the energy taking it all at once gives me as I have actually gotten more accomplished these past few days than I have in months. But I don't like waking up to this either!

I'm thinking maybe I should go back to 37.5 2x a day for 2 weeks and then taking 75mg in the morning and 37.5 in the evening. So that way I have a steady 75mg in my system. Does that sound right or make sense?

I could really use some help here as I feel yucky and just want to go back to bed. Or go vomit. I feel out of it and it's a weird feeling which I don't at all like.

Sounds to me like I'm experiencing a case of withdrawal between doses. That doesn't surprise me as I'm always one who has to take XR versions of meds at least 2x a day.

So what do you suggest? And what do you think is happening? I really need some input as I feel cruddy and just yesterday I felt so good!

Thanks everyone. Take care and have a great day!


Hugs,
CA 2 NJ

Yeah that makes complete sense. I have switched back to meds dose level and kinds many times. Not all mixes work, and psychiatrists allways hit and miss our meds. But after I switch or preferably before I call him and let him know what is going on. He never agrees with me but after a couple of calls he usually gives in.

So call your Pdoc and then switch back, unless he has a better idea.

I have even stopped taking meds and then retried and it worked the second or third time.