"Connect the dots"- to understand the relationship between different ideas or experiences
Dot 1
A South Korean ban on fatal pesticides has been linked to an 11 percent drop in suicide attempts. Health officials hope that the new regulations will continue to curb the booming nation’s soaring suicide rate, which has been the highest in the developed world for nine straight years. But psychiatrists submit that a substantial reduction would require an assessment of deeper issues.
According to Reuters, the recent drop represents the first positive trend in six years. The South Korean government has ascribed the falling statistics to the 2011 restriction and subsequent prohibition of Gramoxone, an herbicidal agent linked to 25 percent of domestic suicides between 2006 and 2010.
http://www.medicaldaily.com/ban-pestici ... op-6-years
Dot 2
"Antipsychotic" drugs originate from pesticide.
Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs. It has the formula S(C6H4)2NH. This yellow tricyclic compound is soluble in acetic acid, benzene, and ether. The compound is related to the thiazine-class of heterocyclic compounds. Derivatives of the parent compound find wide use as drugs.
The synthetic dye methylene blue, containing the structure, was described in 1876. Phenothiazine itself was introduced by DuPont as an insecticide in 1935
The phenothiazine structure occurs in various neuroleptic drugs, e.g. chlorpromazine, and antihistaminic drugs, e.g. promethazine.
The term "phenothiazines" describes the largest of the five main classes of neuroleptic antipsychotic drugs. These drugs have antipsychotic and, often, antiemetic properties, although they may also cause severe side effects such as extrapyramidal symptoms (including akathisia and tardive dyskinesia), hyperprolactinaemia, and the rare but potentially fatal neuroleptic malignant syndrome, as well as substantial weight gain.
See http://en.wikipedia.org/wiki/Phenothiazine
Dot 3
That stuff in Korea "Paraquat" is the trade name for N,N′-dimethyl-4,4 ′-bipyridinium dichloride, one of the most widely used herbicides in the world. Paraquat, a viologen, is quick-acting and non-selective, killing green plant tissue on contact. It is also toxic to human beings and animals. Research has shown that it is linked to development of Parkinson's disease.
http://en.wikipedia.org/wiki/Gramoxone
Dot 4
Parkinson's disease is also caused by neuroleptic antipsychotic drugs.
Parkinson's disease occurs when the nerve cells in the brain that make a checmical called dopamine are slowly destroyed. Dopamine helps control muscle movement. Without dopamine, the nerve cells in that part of the brain cannot properly send messages...
Certain medications can cause secondary parkinsonism, including:
Antipsychotics (haloperidol)
Metoclopramide
Phenothiazine medications
http://www.nlm.nih.gov/medlineplus/ency ... 000759.htm
Dot 5
"Akathisia is a disorder, induced by these "medications", which can cause a person to experience such intense inner restlessness that the sufferer is driven to violence and/or suicide. It has been said, "Death can be a welcome result."
see http://missd.co/
Dot 6
Connect the dots people !!! Stay with me.
Abstract
OBJECTIVE: The authors’ goal was to investigate whether there is a greater suicide risk in the placebo arms of placebo-controlled studies of active medication for the treatment of acute manic episode and the prevention of manic/depressive episode. If so, this would be a strong ethical argument against the conduct of such studies.
METHOD: All placebo-controlled, double-blind, randomized trials of medication for the treatment of acute manic episode and the prevention of manic/depressive episode that were part of a registration dossier submitted to the regulatory authority of the Netherlands, the Medicines Evaluation Board, between 1997 and 2003, were reviewed for occurrence of suicide and attempted suicide.
RESULTS: In 11 placebo-controlled studies of the treatment of acute manic episode, including 1,506 patients (117 person-years) in the combined active compound group and 1,005 patients (71 person-years) in the combined placebo group, no suicides and no suicide attempts occurred. In four placebo-controlled studies of the prevention of manic/depressive episode, including 943 patients (406 person-years) in the combined active compound group and 418 patients (136 person-years) in the combined placebo group, two suicides (493/100,000 person-years of exposure) and eight suicide attempts (1,969/100,000 person-years of exposure) occurred in the combined active compound group, but no suicides and two suicide attempts (1,467/100,000 person-years of exposure) occurred in the combined placebo group.
http://www.ncbi.nlm.nih.gov/pubmed/15800158
Dot 6.5
Storosum and colleagues analyzed all placebo-controlled, double-blind, randomized trials of mood stabilizers for the prevention of manic/depressive episode that were part of a registration dossier submitted to the regulatory authority of the Netherlands, the Medicines Evaluation Board, between 1997 and 2003 [28]. They found four such prophylaxis trials. They compared suicide risk in patients on placebo compared with patients on active medication. Two suicides (493/100,000 person- years of exposure) and eight suicide attempts (1,969/100,000 person-years of exposure) occurred in the group given an active drug (943 patients), but no suicides and two suicide attempts (1,467/100,000 person-years of exposure) occurred in the placebo group (418 patients). Based on these absolute numbers from these four trials, I have calculated (see Figure S1 showing calculation, and see Figure 2) that active agents are most likely to be associated with a 2.22 times greater risk of suicidal acts than placebo (95% CI 0.5, 10.00).
Hows that for dot connecting ?
Does this make sense ?