Kappa opioids are THE cure.

by **addx** » Wed Aug 07, 2013 4:21 pm

Everyone research these receptors

Key areas are kappa opioid involvement in fear response, notable fear memory recall and storage. They opose the reward "mu" opioid, they are the other side of the medal.

A few highlights:

1. Kappa opioid agonists at higher doses cause fear, anxiety, depression and anhedonia - directly and rapidly without any other effects. No other chemical does anything remotely similar.

2. Kappa opioid antagonists stop fear anxiet and depression and restore hedonia directly and rapidly without any other effects(such as sedation or euphoria). No other chemical does anything remotely similar.

3. Kappa opioid antagonists RESTORE normal mood. You can not get high off them. Mu opioids are for getting high. Kappa opioids are the oposition - the inhibition of reward. They can only go so far as to disinhibit.

4. Kappa agonists are the only known chemicals that REVERSE drug tolerance. To ALL drugs. Tolerance is infact the kappa opioid network tone. When consuming drugs the high dopaminergic state causes kappa opioid network upregulation to compensate and reduce all this dopamine - this is development of drug tolerance. To counter it you need to hit the kappa opioid receptors instead of mu opioid. The body will not restore this balance back any time soon as drugs users painfully know.

So... anyone interested in more?

We alcoholics are men and women who had lost the ability to control our drinking. We know that no real alcoholic ever recovered this control. All of us felt at times that we were regaining control, but such intervals - usually brief - were inevitably followed by still less control, which led in time to pitiful and incomprehensible demoralization. We are convinced to a man that alcoholics of our type are in the grip of a progressive illness. Over any considerable period we get worse, never better.

We are like men who have lost their legs; they never grow new ones. Neither does there appear to be any kind of treatment which will make alcoholics of our kind like other men. We have tried every imaginable remedy. In some instances there has been brief recovery, followed always by still worse relapse. Physicians who are familiar with alcoholism agree there is no such thing as making a normal drinker out of an alcoholic. Science may one day accomplish this, but it evidently hasn't done so yet.

http://anonpress.org/bb/Page_31.htm

Tell us about this cure "reversing tolerance"...

by **addx** » Wed Aug 07, 2013 5:33 pm

Here's a very throrough study that is pretty much scientific but there are some animal examples that are easy to understand.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787673/

There is a cure but it has been hidden for years by the fact that Mu opioid receptors are the pleasure ones and cause addicitions and thus the kappa opioids were ignored as well.... thruth is, even natural substances that agonize mu receptors usually antagonize kappa... it's the fear/reward -approach/avoid system. And all these years they only thought of it as rewarding and painkilling. While infact pushing kappa receptors causes bad feelings and fear.

[mod edit]

[mod edit] This thing gets heroin addicts to not think about heroin within 2 days.

Anyway, I'm ordering this thing, I hope it arrives as it's not cheap.

I did a bigger write up of how it all works in the thread "Why it all doesn't work", but that was ignored...

Science IS very close now but it will still take years for them to find something to patent and then test it out...

I'm not telling lies. The only kappa ANTAgonist that has reached human trials is called JDTic. Trial was unfortunately ended due to some heart arrythmia showing up.
Antagonist should instantly reduce fearfullness and restore hedonic tone and obliterate the need for selfmedicating with drugs, so read on:

The only human account of JDTic use except the psychonauts David Pearces is the following:

I have severe Major Depression [ed: PHQ-9 score of 22]. I have Anheodnia, no emotions, very few
feelings, and avoliton. I have severe anxiety. I can hardly speak. I only
answer questions. I do not engage in social conversations because of my severe
thought poverty and inability to process the emotional content in
conversations. I feel frozen, numb and tortured. I have to work confused,
severe memory probelms, trembling and just really screwed up. My life is a
nightmare every day of my life.

I received the JDtic one afternoon. I was so eager to try it I
divided the jdtic into 2mg dosages and put it into capsules. I tried my first dose
that afternoon. The next day I woke up feeling this really warm, clean, healthy
feeling. I felt completley free of anxiety. I kept having involuntary erections for
no reason. I never have an erection for anything. I started watching the television
and I started to have a warm feeling in my stomach from watching my favorite show. I
started to get all these feelings from my body that I never get. I started to get
cold chills from watching a movie. I started to have hunger pains. I never feel
hungry. I walked outside. The breeze felt so good that day. When I went to work. I
looked at people in the face and spoke to them without feeling frozen with anxiety.

The next day I woke up and took the next dose of Jdtic at 10am. I woke up and had
breakfast. I started to watch television. I couldn't stop laughing. I was in a great
mood. I was laughing, talking to the television. I was talking and joking with my
friends through text messages. I went out for lunch with with my only close friend
left. I kept making her laugh. It was wonderful. I've spent my whole adult life not
being able to touch anyone emotionally. Now I can make people laugh. I started to
see the punch line. I started to become really funny. That day at work. I started to
have these really brief, weak emotions. They were really weak and confusing. But I
was really happy to have them. I started to feel touched by music. I felt driven to
sing along with the music. That day I also caught myself looking at a women's
breast. I started to want to look at her body. I never do that. I usually do not
even notice women anymore. My memory also improved. I usually can't remember any of
the streets. That day I remembered all of them and thought of a plan of the best way to
get there, instead of using a gps.

The next week I planned days out with all my old friends. I wanted to be warm and
try to make them feel loved, and make them laugh. I was trying to make up for being
a cold emotionless person to them. I also went to spend time with my grandfather. My
grandfather is dying. I was too messed to go and see him. I tried my best to be warm
and affectionate to him.

The last few days of the trial. I started to have moments where I felt like my life
had a sense of urgency. I felt like I had to do things. I felt like I had to go home
and read my science books. I'm not sure if I would call it motivation. I just had
these moments where I really wanted to find my vocation in life. I was going to
college for chemical engeneering before I got sick. I just kept having this urgent
feeling that I wanted to finish.

JDTic was very helpful. I still had problems, but I was slowly starting to feel
better. I'm not sure what would happen if I continued to take it. I would love to
find out. I hope that I was helpful. I'm a little tired. I hope I remembered
everything

Now, I can't tell if this is fake but I can't see nothing wrong about it and it's exactly what I would except if someone so deeply fearfull and depressed was suddenly releived of it correctly.
Incorrectly would be to take an SSRI, wait 2 weeks, then go through 2 weeks of suicide ideation, and then after 2 weeks more you may become a zombie and this will enable you to walk around and exist as a lesser burden to whomever you are a burden.

by **Devilock** » Thu Aug 08, 2013 8:40 am

do u know anything about if u took kappa opiods whilst on the medication subutex? I know subutex blocks some opiod receptors and I take subutex so im quite worried about the brain damaging? effects of blocking half yr opiod receptors? just curious,,, thx

by **addx** » Thu Aug 08, 2013 11:35 am

Kind of a good question to clarify a bit and add to the thread, but definitely I would not advise any kind of mixing with subutex, especially [mod edit] it will very possibly kill you.

Subutex is a kappa opioid antagonist(blocker) and a mu opioid agonist(activator).

kappa is fear, mu is reward.

subutex is a lot weaker at mu than opioids like herion/vicodin/etc - thus it is not considered THAT abuseable. main action of subutex is actually kappa opioid receptor antagonism.

as explained, kappa opioid network(fear) is opposed to mu opioid network(reward)... so abusing the mu opioid network causes the kappa opioid network to upregulate to compensate(infact it might not even upregulate to compensate directly for mu action but to inhibit the extreme levels of dopamine that result from ANY drug abuse and that are neurotoxic).
the amount of upregulation of the kappa opioid network constitutes the level of tolerance developed and the intensity of the withdrawal. once the exogenous source of mu opioid activators(heroin) is removed the upregulated kappa opioid network squashes any will to live basicly. it takes years for it to return to normal and allow happiness. subutex antagonizes kappa opioid receptors which means it pretty much takes away the feeling of withdrawal(life squashing) but it doesnt speed up the tolerance reversal/downregulation of kappa opioid network. it doesnt speed up the process.

by **knackers323** » Mon Oct 05, 2015 1:28 am

Anyone tried any of this?

Kappa opioids are THE cure.

Kappa opioids are THE cure.

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