Upper Legs muscles cramp only when sleeping

I’m going on 7 weeks of the weirdest symptoms. I’ve been to my primary Dr, a sports medicine Dr and a Sleep Dr and none can confirm what’s going on. I see an Neuro Muscular Dr on Monday. This issue is only when I sleep so it’s not induced by body position. Once I fall asleep, I wake up every 1.5-2.0 hours every night and always on that schedule. I haven’t had one night making it 3 straight hours. When I wake up, my upper legs are really tight and when I straighten them they spasm and the cramp releases and I can go right back to sleep. This pattern continues night after night. I’ve tried everything, epsom salt baths, quinine, thc, CBD, prescription muscle relaxers, warm baths, stretching, foam roller, heat pad, ice…you name it and I’ve tried it. Has anyone heard of this before and have any suggestions that I can ask the neurologist about on Monday? I’ve also had sporadic muscle twitching since last March, 2022 but don’t have any muscle weakness. Thank you for any help.

I'm really sorry to hear about your ongoing struggle with these symptoms. It's great that you have an upcoming appointment with a Neuro Muscular Dr – hopefully, they can provide some answers and solutions. It's important to share all your symptoms, including the muscle twitching, with them. Hang in there, and I hope you find some relief soon.