Nature's wide array of chemistry has some good herbal based chemicals that have an adaptive effect via in conjunction with the NMDA receptor instead of directly inhibiting dopamine and 5ht receptors with non nature based toxins.
Some natural solutions might have a non addictive calming anti-psychotic effect and actually be positive with regards to their impact on neuro degenerative disorders so there would be no brain shrinking and we're probably talking one or two obscure ...