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GABA Relationship to Bulimia

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GABA Relationship to Bulimia

Postby persistentone » Thu Aug 03, 2017 9:34 am

There are some interesting studies that show that patients with bulimia have higher numbers of abnormalities in the genes/SNPs related to the neurotransmitter GABA. For example:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176559/

Does anyone know of a study that tries to administer GABA in its free form as a powder, or GABA in a lipid form as an under-tongue spray, to observe its effects on patients with bulimia? It's not clear to me from the above study do we want to increase or decrease GABA in these patients.
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Re: GABA Relationship to Bulimia

Postby frangiflossi » Sun Dec 24, 2017 4:31 am

From what I know about Nardil (basically my dream med that I'm trying to get right now for social phobia and depression), Nardil inhibits GABA-T, which breaks down GABA. We don't want GABA to be broken down too fast. Low levels of GABA are a mental health no-no, and point to anxiety/mood problems.

Weirdly, a psychiatrist recently told me that Nardil doesn't affect GABA, which she is blatantly wrong about. Easily accessible studies literally state the exact opposite, that Nardil has GABA-elevating effects. This still confuses me as to why she would state that. What's even more convenient is that I'm BPD, and it's kind of triggered a she's-doing-it-on-purpose-to-stop-me-from-getting-better complex. Yay.

Seems like if bulimia needs higher GABA, and social anxiety needs higher GABA, then Nardil is like a golden med for me.
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