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MirageXD
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Switching from coffee to tea
   Sun Dec 11, 2011 10:41 pm

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Switching from coffee to tea

Permanent Linkby MirageXD on Sun Dec 11, 2011 10:41 pm

That's right, I decided to quit coffee for now, because it seems to increase my adrenaline levels, which makes me shake quite a bit. I used to tolerate coffee quite well, but after drinking 3-6 large cups of coffee a day, my organism decided that it's enough.

Therefore, I decided to try tea as a replacement. The thing is that tea doesn't have the same wakening effects for me as coffee.

Nevertheless, I already plan to introduce another drug into the mix which should help me with staying awake during the day and more. I might post about it later if it's successful.

As for the type of tea I drink, I like earl grey or a herbal tea (from my mom).

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Do nerve agents improve cognition? (permanently)

Permanent Linkby MirageXD on Tue Aug 16, 2011 2:10 pm

I've been reading about cholinergics which improve cognitive abilities, and I discovered an interesting fact. Most nerve agents work like cholinergics! The problem is that nerve agents (sarin, VX) are toxic, so they in fact cause brain damage, which in turn kills you, unless you administer a strong anticholinergic such as atropine.

I just thought it's interesting that the same action used to treat cognitive impairment is used to kill people.

Please, don't use this as a guide to improve your cognition! :lol:

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Abilify sucks

Permanent Linkby MirageXD on Sun Aug 14, 2011 2:10 pm

I decided to try Abilify again to see if it could improve my cognitive problems. I did try it before, but it had some nasty side effects for me: nausea, increased sweating, blurred vision, difficulty speaking... I didn't even try its antipsychotic properties since I discontinued it quickly.

Abilify is well known for its transient side effects which pass within two weeks, so I decided to give it another try. This time, I titrated it from 5mg. To avoid nausea, I took it with food, and indeed, it worked, bacause the pill didn't dissolve in my stomach. Nausea causes increased sweating, so I fixed this also.

I figured out that some antihistamines cause difficulty speaking, but Abilify has a very weak affinity for H1 receptor, so it shouldn't cause any problems, but it does cause difficulty speaking regardless. This is the main reason I discontinued it again.

I suspect that antipsychotic properties suck as well at 5mg, because after decreasing my previous antipsychotic (sulpiride), I felt some anxiety and psychosis returning. Well, it shouldn't happen, because I decreased the dose of sulpiride by only 33%. 5mg of Abilify should compensate for this, and I'm not willing to experiment with that when it obviously sucks.

Of course, it may work for someone else.

Now, I just want to try lurasidone (Latuda) once it is available in the Czech Republic. It's supposed to improve cognitive skills better than any other antipsychotic, and it has no affinity for H1 receptor, so no difficulty speaking for me (hopefully).

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My new espresso

Permanent Linkby MirageXD on Thu Aug 04, 2011 8:30 pm

I got myself a new fully automatic espresso machine. It's an upgrade over my old Dolce Gusto.

The old machine had a major problem. It only worked with one type of capsules (as far as I know), and the coffee had a very strange taste. I do like cappuccino, but it was too bitter for my tastes. In fact, the only drink I used to like was chococino, and that's not even coffee. Dolce Gusto was a cheap machine, and I think I'm gonna give it to my family. :lol:

The new machine has a lot of functions, and makes coffee the right way. It even has the auto-cappuccino function which makes a nice foam. I still have to figure out the right type of milk for the foam. I bought the most expensive beans I could find, and the taste isn't bad. :mrgreen:

We have a similar espresso at my work, but it cannot make cappuccino or latte the easy way. Since I'm on antipsychotics, I drink like 4 cups of coffee every day to stay awake. I'm so used to the taste of this coffee that it will be hard to learn to like any other.

The best cappuccino I tasted was made by a vending machine. I don't know how they make it so good. Well, not all machines are the same.

Espress yourself. :D
Last edited by MirageXD on Thu Aug 04, 2011 8:34 pm, edited 1 time in total.

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Dopamine blocker + non-sedating antihistamine = works for me

Permanent Linkby MirageXD on Mon Jul 11, 2011 11:00 pm

Three years ago, I was diagnosed with paranoid schizophrenia. I've been trying various meds using trial and error approach as well as pharmacology. In fact, I've been telling my doctor what to prescribe for the last two years, because he's not willing to take the time to study my illness more closely.

The first year, I've been on Olanzapine which among other things caused difficulty speaking. I later diagnosed this as cortical dysarthria, because my doctor doesn't know how to diagnose this.

After trying almost all atypical antipsychotics, I came up with the following combination which sorta works: 400mg of Sulpiride and 25mg of Quetiapine. Sulpiride is a selective dopamine antagonist, while Quetiapine works as a histamine and alpha blocker at low doses such as 25mg. Sulpiride causes mild insomnia, and that's all. Quetiapine causes difficulty speaking as well though.

Being on a low dose of Sulpiride for a few years caused some cognitive (memory) problems. I had to increase the dose to 600mg to fix them, but I still struggle with them sometimes.

My theory was that I could replace Quetiapine by an alpha blocker to prevent my other symptoms like a tremor and watery eyes. My doc didn't want to prescribe an alpha blocker, because it would be an off-label use, and he's not much into experimentation. I am. :mrgreen:

I then contacted about 60 doctors, and two of them agreed that they would prescribe it. Victory? Not really, because it didn't work. :roll:

My latest theory was that I could replace Quetiapine by an antihistamine. To my great surprise, you can get an antihistamine without prescription, and there are even second generation antihistamines which don't cause sedation. Nice! One of them also caused difficulty speaking, so that means that blocking H1 receptor causes this.

To sum it up, I'm now on 600mg of Sulpiride (dopamine blocker) and 5mg of Loratadine (antihistamine).

My remaining symptoms: slightly burning eyes, and mild cognitive problems
My side effects: nothing worth mentioning!

All in all, a great success in treating schizophrenia.

Sorry if this was too technical, but I didn't even talk about pharmacology behind this. :lol:

Mirage

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