Like Omnicell said, Mr. Anxiety, you can't just make assumptions about somebody's motives in a situation like that. I recently attended a snooty Canadian university as a mature student. It took me a few months to get used to the subtleties of Hipster Sarcasm. No, you don't want to let somebody punk you, but you don't want to hurt somebody who's offering you a sincere compliment, either.
Maybe she thinks those Jersey Whore guys are hot, and that was her way of flirting with you.
The best response to that kind of ambiguity (or irony) is the equally ambiguous (and ironic) Spock Stare. Draw yourself up to your full height, incline your head ever so slightly, and cock one eyebrow if you can manage it. Say--softly--no yelling: "And your point is?" This is the Tabula Rasa comeback, so named by Yours Truly. Your beholder is free to project anything s/he wants onto your blank stare.
Flirts will perceive it as a sexy invitation to continue flirting. Macho dicks will perceive it as a challenge. Good-natured jokers will usually try harder to be funny enough to get you to crack a smile. Just make sure you respond appropriately to the second stage of communication (more flirting, more chestpounding, crack a smile, etc.)
4 real. It works
If the girl hasn't gone and jumped off a bridge, and you can get a hold of one of her friends from the party, you might want to ask if it's possible to console her, and what might be a good way to do it. Just be careful with trying to patch things up at this point. It might not be worth it at all. She might perceive you as one of those mean, fickle PUA guys. Make sure you ask somebody you both know reasonably well, and be prepared to let it all go if that's what has to be done.